![]() ![]() Although untreated severe malaria is nearly always fatal, with timely and effective treatment, the death rate due to malaria in the US is less than 2%. Individuals at high risk of severe disease include young children, pregnant persons, older travelers, and people who are immunosuppressed. ![]() Severe malaria, which is typically associated with a high blood level of Plasmodium parasites, may result in decreased consciousness, seizures, difficulty breathing, severe anemia, and multiorgan failure. First-line treatment involves immediate administration of antimalaria medication. Therefore, early diagnosis and treatment of uncomplicated malaria is important. ![]() Uncomplicated malaria due to Plasmodium falciparum can rapidly progress to severe malaria. Patients with uncomplicated malaria have symptoms and a positive malaria test result without features of severe malaria. Rapid diagnostic tests that detect parasite-specific molecules in a blood sample may also be used to diagnose malaria.
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